Expected winners today:
| Region | High Seed | Low Seed | Chance of winning |
|---|---|---|---|
| South | (2) Marquette | (7) Colorado | 54.33% |
| Midwest | (1) Purdue | (8) Utah St | 64.27% |
| South | (4) Duke | (12) JMU | 60.76% |
| West | (3) Baylor | (6) Clemson | 53.31% |
| West | (4) Alabama | (12) Grand Canyon | 55.94% |
| East | (1) UConn | (9) Northwestern | 67.42% |
| South | (1) Houston | (9) Texas A&M | 69.80% |
| East | (5) San Diego St | (13) Yale | 63.93% |