| Rank | Team | Wins | Losses | Runs Scored | Runs Allowed | Bill James | Difference | Combined |
|---|---|---|---|---|---|---|---|---|
| 1 | Los Angeles Dodgers | 106 | 56 | 830 | 561 | 109.178 | -3.178 | 132.826 |
| 2 | San Francisco Giants | 107 | 55 | 804 | 594 | 103.177 | 3.823 | 129.739 |
| 3 | Tampa Bay Rays | 100 | 62 | 857 | 651 | 101.656 | -1.656 | 124.479 |
| 4 | Houston Astros | 95 | 67 | 863 | 658 | 101.437 | -6.437 | 121.257 |
| 5 | Chicago White Sox | 93 | 69 | 796 | 636 | 97.742 | -4.742 | 117.742 |
| 6 | Toronto Blue Jays | 91 | 71 | 846 | 663 | 99.403 | -8.403 | 117.533 |
| 7 | Milwaukee Brewers | 95 | 67 | 738 | 623 | 93.536 | 1.464 | 116.380 |
| 8 | Atlanta Braves | 88 | 73 | 790 | 656 | 94.406 | -6.406 | 113.296 |
| 9 | Boston Red Sox | 92 | 70 | 829 | 749 | 88.874 | 3.126 | 111.651 |
| 10 | New York Yankees | 92 | 70 | 711 | 669 | 85.556 | 6.444 | 109.602 |
| 11 | St. Louis Cardinals | 90 | 72 | 706 | 672 | 84.693 | 5.307 | 107.835 |
| 12 | Oakland Athletics | 86 | 76 | 743 | 687 | 86.919 | -0.919 | 106.740 |
| 13 | Cincinnati Reds | 83 | 79 | 786 | 760 | 83.602 | -0.602 | 102.841 |
| 14 | Seattle Mariners | 90 | 72 | 697 | 748 | 75.648 | 14.352 | 102.252 |
| 15 | San Diego Padres | 79 | 83 | 729 | 708 | 83.214 | -4.214 | 100.132 |
| 16 | Philadelphia Phillies | 82 | 80 | 734 | 745 | 79.864 | 2.136 | 99.916 |
| 17 | Cleveland Indians | 80 | 82 | 717 | 727 | 79.949 | 0.051 | 98.734 |
| 18 | New York Mets | 77 | 85 | 636 | 668 | 77.385 | -0.385 | 95.299 |
| 19 | Detroit Tigers | 77 | 85 | 697 | 756 | 74.835 | 2.165 | 93.726 |
| 20 | Los Angeles Angels | 77 | 85 | 723 | 804 | 72.84 | 4.16 | 92.494 |
| 21 | Colorado Rockies | 74 | 87 | 739 | 796 | 74.797 | -0.797 | 92.421 |
| 22 | Kansas City Royals | 74 | 88 | 686 | 788 | 70.479 | 3.521 | 89.185 |
| 23 | Minnesota Twins | 73 | 89 | 729 | 834 | 70.613 | 2.387 | 88.650 |
| 24 | Miami Marlins | 67 | 95 | 623 | 701 | 72.303 | -5.303 | 85.990 |
| 25 | Chicago Cubs | 71 | 91 | 705 | 839 | 67.662 | 3.338 | 85.594 |
| 26 | Washington Nationals | 65 | 97 | 724 | 820 | 71.414 | -6.414 | 84.206 |
| 27 | Texas Rangers | 60 | 102 | 625 | 815 | 61.279 | -1.279 | 74.864 |
| 28 | Pittsburgh Pirates | 61 | 101 | 609 | 833 | 57.902 | 3.098 | 73.396 |
| 29 | Arizona Diamondbacks | 52 | 110 | 679 | 893 | 60.177 | -8.177 | 69.245 |
| 30 | Baltimore Orioles | 52 | 110 | 659 | 956 | 53.046 | -1.046 | 64.843 |