| Rank | Team | Wins | Losses | Runs Scored | Runs Allowed | Bill James | Difference | Combined |
|---|---|---|---|---|---|---|---|---|
| 1 | Los Angeles Dodgers | 43 | 17 | 349 | 213 | 43.126 | -0.126 | 143.544 |
| 2 | Tampa Bay Rays | 40 | 20 | 289 | 229 | 36.381 | 3.619 | 127.302 |
| 3 | San Diego Padres | 37 | 23 | 325 | 241 | 38.318 | -1.318 | 125.530 |
| 4 | Minnesota Twins | 36 | 24 | 269 | 215 | 36.036 | -0.036 | 120.060 |
| 5 | Chicago White Sox | 35 | 25 | 306 | 246 | 36.103 | -1.103 | 118.505 |
| 6 | Oakland Athletics | 36 | 24 | 274 | 232 | 34.567 | 1.433 | 117.611 |
| 7 | Atlanta Braves | 35 | 25 | 348 | 288 | 35.526 | -0.526 | 117.543 |
| 8 | Cleveland Indians | 35 | 25 | 248 | 209 | 34.561 | 0.439 | 115.934 |
| 9 | New York Yankees | 33 | 27 | 315 | 270 | 34.413 | -1.413 | 112.355 |
| 10 | Chicago Cubs | 34 | 26 | 265 | 240 | 32.732 | 1.268 | 111.220 |
| 11 | St. Louis Cardinals | 30 | 28 | 240 | 229 | 30.239 | -0.239 | 103.860 |
| 12 | Toronto Blue Jays | 32 | 28 | 302 | 312 | 29.048 | 2.952 | 101.746 |
| 13 | Cincinnati Reds | 31 | 29 | 243 | 243 | 30.0 | 1.0 | 101.667 |
| 14 | Houston Astros | 29 | 31 | 279 | 275 | 30.41 | -1.41 | 99.017 |
| 15 | San Francisco Giants | 29 | 31 | 299 | 297 | 30.195 | -1.195 | 98.658 |
| 16 | Philadelphia Phillies | 28 | 32 | 306 | 311 | 29.525 | -1.525 | 95.876 |
| 17 | Milwaukee Brewers | 29 | 31 | 247 | 264 | 28.156 | 0.844 | 95.260 |
| 18 | Miami Marlins | 31 | 29 | 263 | 304 | 25.886 | 5.114 | 94.810 |
| 19 | Washington Nationals | 26 | 34 | 293 | 301 | 29.22 | -3.22 | 92.033 |
| 20 | New York Mets | 26 | 34 | 286 | 308 | 27.857 | -1.857 | 89.762 |
| 21 | Los Angeles Angels | 26 | 34 | 294 | 321 | 27.436 | -1.436 | 89.060 |
| 22 | Kansas City Royals | 26 | 34 | 248 | 272 | 27.431 | -1.431 | 89.052 |
| 23 | Baltimore Orioles | 25 | 35 | 274 | 294 | 27.989 | -2.989 | 88.314 |
| 24 | Arizona Diamondbacks | 25 | 35 | 269 | 295 | 27.374 | -2.374 | 87.290 |
| 25 | Seattle Mariners | 27 | 33 | 254 | 303 | 25.031 | 1.969 | 86.718 |
| 26 | Colorado Rockies | 26 | 34 | 275 | 353 | 22.795 | 3.205 | 81.325 |
| 27 | Boston Red Sox | 24 | 36 | 292 | 351 | 24.607 | -0.607 | 81.011 |
| 28 | Detroit Tigers | 23 | 35 | 249 | 318 | 22.3 | 0.7 | 78.103 |
| 29 | Texas Rangers | 22 | 38 | 224 | 312 | 20.97 | 1.03 | 71.617 |
| 30 | Pittsburgh Pirates | 19 | 41 | 219 | 298 | 21.653 | -2.653 | 67.756 |