| Rank | Team | Wins | Losses | Runs Scored | Runs Allowed | Bill James | Difference | Combined |
|---|---|---|---|---|---|---|---|---|
| 1 | Houston Astros | 107 | 55 | 920 | 640 | 108.073 | -1.073 | 132.761 |
| 2 | Los Angeles Dodgers | 106 | 56 | 886 | 613 | 108.159 | -2.159 | 132.197 |
| 3 | New York Yankees | 103 | 59 | 943 | 739 | 99.966 | 3.034 | 125.288 |
| 4 | Minnesota Twins | 101 | 61 | 939 | 754 | 98.163 | 2.837 | 122.940 |
| 5 | Oakland Athletics | 97 | 65 | 845 | 680 | 97.51 | -0.51 | 120.068 |
| 6 | Tampa Bay Rays | 96 | 66 | 769 | 656 | 92.926 | 3.074 | 116.621 |
| 7 | Atlanta Braves | 97 | 65 | 855 | 743 | 91.902 | 5.098 | 116.606 |
| 8 | Washington Nationals | 93 | 69 | 873 | 724 | 95.46 | -2.46 | 116.333 |
| 9 | Cleveland Indians | 93 | 69 | 769 | 657 | 92.816 | 0.184 | 114.701 |
| 10 | St. Louis Cardinals | 91 | 71 | 764 | 662 | 91.77 | -0.77 | 112.821 |
| 11 | Chicago Cubs | 84 | 78 | 814 | 717 | 90.743 | -6.743 | 107.866 |
| 12 | Arizona Diamondbacks | 85 | 77 | 813 | 743 | 87.963 | -2.963 | 106.767 |
| 13 | New York Mets | 86 | 76 | 791 | 737 | 86.445 | -0.445 | 106.447 |
| 14 | Boston Red Sox | 84 | 78 | 901 | 828 | 87.736 | -3.736 | 106.010 |
| 15 | Milwaukee Brewers | 89 | 73 | 769 | 766 | 81.302 | 7.698 | 105.125 |
| 16 | Philadelphia Phillies | 81 | 81 | 774 | 794 | 79.018 | 1.982 | 98.777 |
| 17 | Cincinnati Reds | 75 | 87 | 701 | 711 | 79.932 | -4.932 | 95.637 |
| 18 | Texas Rangers | 78 | 84 | 810 | 878 | 74.616 | 3.384 | 94.208 |
| 19 | San Francisco Giants | 77 | 85 | 678 | 773 | 71.086 | 5.914 | 91.411 |
| 20 | Los Angeles Angels | 72 | 90 | 769 | 868 | 71.518 | 0.482 | 88.591 |
| 21 | Chicago White Sox | 72 | 89 | 708 | 832 | 68.178 | 3.822 | 87.067 |
| 22 | Colorado Rockies | 71 | 91 | 835 | 958 | 69.974 | 1.026 | 87.021 |
| 23 | San Diego Padres | 70 | 92 | 682 | 789 | 69.952 | 0.048 | 86.390 |
| 24 | Toronto Blue Jays | 67 | 95 | 726 | 828 | 70.866 | -3.866 | 85.102 |
| 25 | Seattle Mariners | 68 | 94 | 758 | 893 | 68.184 | -0.184 | 84.064 |
| 26 | Pittsburgh Pirates | 69 | 93 | 758 | 911 | 66.611 | 2.389 | 83.711 |
| 27 | Kansas City Royals | 59 | 103 | 691 | 869 | 63.499 | -4.499 | 75.616 |
| 28 | Miami Marlins | 57 | 105 | 615 | 808 | 60.811 | -3.811 | 72.723 |
| 29 | Baltimore Orioles | 54 | 108 | 729 | 981 | 58.001 | -4.001 | 69.137 |
| 30 | Detroit Tigers | 47 | 114 | 582 | 915 | 47.938 | -0.938 | 58.968 |