| Rank | Team | Wins | Losses | Runs Scored | Runs Allowed | Bill James | Difference | Combined |
|---|---|---|---|---|---|---|---|---|
| 1 | New York Yankees | 103 | 59 | 915 | 753 | 96.227 | 6.773 | 122.980 |
| 2 | Los Angeles Dodgers | 95 | 67 | 780 | 611 | 99.025 | -4.025 | 119.768 |
| 3 | Los Angeles Angels of Anaheim | 97 | 65 | 883 | 761 | 92.63 | 4.37 | 117.055 |
| 4 | Boston Red Sox | 95 | 67 | 872 | 736 | 94.152 | 0.848 | 116.760 |
| 5 | Philadelphia Phillies | 93 | 69 | 820 | 709 | 92.148 | 0.852 | 114.289 |
| 6 | Colorado Rockies | 92 | 70 | 804 | 715 | 89.995 | 2.005 | 112.343 |
| 7 | St. Louis Cardinals | 91 | 71 | 730 | 640 | 90.786 | 0.214 | 112.214 |
| 8 | Atlanta Braves | 86 | 76 | 735 | 641 | 91.186 | -5.186 | 109.374 |
| 9 | San Francisco Giants | 88 | 74 | 657 | 611 | 86.299 | 1.701 | 107.592 |
| 10 | Minnesota Twins | 87 | 76 | 817 | 765 | 86.638 | 0.362 | 106.526 |
| 11 | Texas Rangers | 87 | 75 | 784 | 740 | 85.447 | 1.553 | 106.448 |
| 12 | Tampa Bay Rays | 84 | 78 | 803 | 754 | 85.876 | -1.876 | 104.862 |
| 13 | Florida Marlins | 87 | 75 | 772 | 766 | 81.603 | 5.397 | 104.076 |
| 14 | Chicago Cubs | 83 | 78 | 707 | 672 | 84.282 | -1.282 | 103.902 |
| 15 | Detroit Tigers | 86 | 77 | 743 | 745 | 81.293 | 4.707 | 102.634 |
| 16 | Seattle Mariners | 85 | 77 | 640 | 692 | 75.218 | 9.782 | 98.900 |
| 17 | Chicago White Sox | 79 | 83 | 724 | 732 | 80.164 | -1.164 | 98.250 |
| 18 | Toronto Blue Jays | 75 | 87 | 798 | 771 | 83.674 | -8.674 | 97.947 |
| 19 | Milwaukee Brewers | 80 | 82 | 785 | 818 | 77.782 | 2.218 | 97.396 |
| 20 | Oakland Athletics | 75 | 87 | 759 | 761 | 80.797 | -5.797 | 96.171 |
| 21 | Cincinnati Reds | 78 | 84 | 673 | 723 | 75.623 | 2.377 | 94.829 |
| 22 | Arizona Diamondbacks | 70 | 92 | 720 | 782 | 74.674 | -4.674 | 89.305 |
| 23 | San Diego Padres | 75 | 87 | 638 | 769 | 67.074 | 7.926 | 87.700 |
| 24 | New York Mets | 70 | 92 | 671 | 757 | 71.917 | -1.917 | 87.603 |
| 25 | Houston Astros | 74 | 88 | 643 | 770 | 67.534 | 6.466 | 87.367 |
| 26 | Cleveland Indians | 65 | 97 | 773 | 865 | 72.188 | -7.188 | 84.684 |
| 27 | Baltimore Orioles | 64 | 98 | 741 | 876 | 67.995 | -3.995 | 81.478 |
| 28 | Kansas City Royals | 65 | 97 | 686 | 842 | 65.395 | -0.395 | 80.491 |
| 29 | Pittsburgh Pirates | 62 | 99 | 636 | 768 | 66.511 | -4.511 | 79.820 |
| 30 | Washington Nationals | 59 | 103 | 710 | 874 | 65.019 | -6.019 | 76.555 |