| Rank | Name | Team | G | Batters Faced | IP | TBA | TOP |
|---|---|---|---|---|---|---|---|
| 1 | Andrew Bailey | OAK | 68 | 323 | 83.1 | 98 | 0.306 |
| 2 | Brian Wilson | SFG | 68 | 303 | 72.1 | 113 | 0.378 |
| 3 | Luke Gregerson | SDP | 72 | 318 | 75.0 | 121 | 0.384 |
| 4 | Michael Wuertz | OAK | 74 | 304 | 78.2 | 117 | 0.387 |
| 5 | Matt Guerrier | MIN | 79 | 304 | 76.1 | 117 | 0.389 |
| 6 | Rafael Soriano | ATL | 77 | 307 | 75.2 | 118 | 0.389 |
| 7 | Rob Tejeda | KCR | 35 | 313 | 73.2 | 123 | 0.395 |
| 8 | Jake Peavy | TOT | 16 | 410 | 101.2 | 165 | 0.405 |
| 9 | Érik Bédard | SEA | 15 | 348 | 83.0 | 141 | 0.408 |
| 10 | Ramón Troncoso | LAD | 73 | 357 | 82.2 | 143 | 0.409 |
| 11 | Brandon Lyon | DET | 65 | 314 | 78.2 | 127 | 0.411 |
| 12 | C.J. Wilson | TEX | 74 | 323 | 73.2 | 132 | 0.412 |
| 13 | Phil Hughes | NYY | 51 | 351 | 86.0 | 145 | 0.413 |
| 14 | Ryan Rowland-Smith | SEA | 15 | 401 | 96.1 | 166 | 0.415 |
| 15 | Mark Lowe | SEA | 75 | 339 | 80.0 | 142 | 0.419 |
| 16 | Todd Coffey | MIL | 78 | 336 | 83.2 | 140 | 0.419 |
| 17 | D.J. Carrasco | CHW | 49 | 405 | 93.1 | 169 | 0.420 |
| 18 | Brian Duensing | MIN | 24 | 359 | 84.0 | 150 | 0.421 |
| 19 | Alfredo Aceves | NYY | 43 | 337 | 84.0 | 142 | 0.423 |
| 20 | Peter Moylan | ATL | 87 | 309 | 73.0 | 129 | 0.423 |
| 21 | Burke Badenhop | FLA | 35 | 303 | 72.0 | 127 | 0.423 |
| 22 | Ryan Madson | PHI | 79 | 320 | 77.1 | 135 | 0.426 |
| 23 | Carlos Marmól | CHC | 79 | 335 | 74.0 | 142 | 0.429 |
| 24 | J.C. Gutiérrez | ARI | 65 | 307 | 71.0 | 132 | 0.433 |
| 25 | John Grabow | TOT | 75 | 314 | 72.1 | 136 | 0.435 |
| 26 | Lance Cormier | TBR | 53 | 331 | 77.1 | 143 | 0.435 |
| 27 | John Maine | NYM | 15 | 349 | 81.1 | 150 | 0.437 |
| 28 | Chan Ho Park | PHI | 45 | 362 | 83.1 | 158 | 0.438 |
| 29 | Brad Ziegler | OAK | 69 | 313 | 73.1 | 137 | 0.439 |
| 30 | Jeff Fulchino | HOU | 61 | 336 | 82.0 | 146 | 0.440 |
| 31 | Shawn Camp | TOR | 59 | 333 | 79.2 | 147 | 0.443 |
| 32 | Hiroki Kuroda | LAD | 21 | 485 | 117.1 | 213 | 0.446 |
| 33 | Mike Gonzalez | ATL | 80 | 315 | 74.1 | 138 | 0.447 |
| 34 | Sean Green | NYM | 79 | 316 | 69.2 | 144 | 0.462 |
| 35 | Edward Mujica | SDP | 67 | 393 | 93.2 | 182 | 0.464 |
| 36 | Fernando Rodney | DET | 73 | 330 | 75.2 | 153 | 0.469 |
| 37 | Homer Bailey | CIN | 20 | 496 | 113.1 | 231 | 0.470 |
| 38 | Bobby Parnell | NYM | 68 | 413 | 88.1 | 193 | 0.471 |
| 39 | Tony Peña | TOT | 72 | 312 | 70.0 | 146 | 0.471 |
| 40 | Jamey Wright | KCR | 65 | 350 | 79.0 | 163 | 0.471 |
| 41 | Clay Buchholz | BOS | 16 | 399 | 92.0 | 188 | 0.474 |
| 42 | Brandon McCarthy | TEX | 17 | 420 | 97.1 | 199 | 0.474 |
| 43 | Kip Wells | TOT | 33 | 314 | 72.2 | 147 | 0.474 |
| 44 | Tim Stauffer | SDP | 14 | 316 | 73.0 | 149 | 0.475 |
| 45 | Ross Detwiler | WSN | 15 | 341 | 75.2 | 160 | 0.475 |
| 46 | Tommy Hunter | TEX | 19 | 475 | 112.0 | 226 | 0.478 |
| 47 | Ramón Ramírez | BOS | 70 | 301 | 69.2 | 143 | 0.480 |
| 48 | Aaron Heilman | CHC | 70 | 313 | 72.1 | 146 | 0.480 |
| 49 | Jordan Zimmermann | WSN | 16 | 391 | 91.1 | 186 | 0.482 |
| 50 | Charlie Morton | PIT | 18 | 416 | 97.0 | 200 | 0.482 |
| 51 | Chad Durbin | PHI | 59 | 314 | 69.2 | 152 | 0.489 |
| 52 | Brian Stokes | NYM | 69 | 316 | 70.1 | 153 | 0.489 |
| 53 | Brad Thompson | STL | 32 | 345 | 80.0 | 168 | 0.490 |
| 54 | Brandon League | TOR | 67 | 313 | 74.2 | 151 | 0.490 |
| 55 | Sean Marshall | CHC | 55 | 373 | 85.1 | 180 | 0.492 |
| 56 | Jason Vargas | SEA | 23 | 385 | 91.2 | 189 | 0.495 |
| 57 | Nelson Figueroa | NYM | 16 | 320 | 70.1 | 157 | 0.495 |
| 58 | Brandon Morrow | SEA | 26 | 313 | 69.2 | 155 | 0.497 |
| 59 | Chris Jakubauskas | SEA | 35 | 390 | 93.0 | 194 | 0.497 |
| 60 | Zach Miner | DET | 51 | 409 | 92.1 | 203 | 0.499 |
| 61 | Matt Albers | BAL | 56 | 309 | 67.0 | 152 | 0.500 |
| 62 | Miguel Batista | SEA | 56 | 326 | 71.1 | 161 | 0.500 |
| 63 | Carlos Villanueva | MIL | 64 | 422 | 96.0 | 210 | 0.502 |
| 64 | Shairon Martis | WSN | 15 | 377 | 85.2 | 187 | 0.503 |
| 65 | Glen Perkins | MIN | 18 | 423 | 96.1 | 213 | 0.505 |
| 66 | Sean West | FLA | 20 | 467 | 103.1 | 235 | 0.509 |
| 67 | Aníbal Sánchez | FLA | 16 | 383 | 86.0 | 194 | 0.509 |
| 68 | Mike Hampton | HOU | 21 | 494 | 112.0 | 250 | 0.518 |
| 69 | Brian Bass | BAL | 48 | 400 | 86.1 | 206 | 0.519 |
| 70 | Jeff Weaver | LAD | 28 | 355 | 79.0 | 182 | 0.520 |
| 71 | Garrett Mock | WSN | 28 | 422 | 91.1 | 218 | 0.522 |
| 72 | Russ Ortiz | HOU | 23 | 387 | 85.2 | 201 | 0.522 |
| 73 | John Smoltz | TOT | 15 | 344 | 78.0 | 179 | 0.523 |
| 74 | Craig Stammen | WSN | 19 | 448 | 105.2 | 233 | 0.525 |
| 75 | Andrew Miller | FLA | 20 | 366 | 80.0 | 189 | 0.525 |
| 76 | J.D. Martin | WSN | 15 | 341 | 77.0 | 178 | 0.528 |
| 77 | Billy Buckner | ARI | 16 | 342 | 77.1 | 183 | 0.538 |
| 78 | Gio Gonzalez | OAK | 20 | 455 | 98.2 | 244 | 0.539 |
| 79 | Kevin Slowey | MIN | 16 | 394 | 90.2 | 211 | 0.540 |
| 80 | Jeff Karstens | PIT | 39 | 471 | 108.0 | 251 | 0.540 |
| 81 | Mark Hendrickson | BAL | 53 | 457 | 105.0 | 248 | 0.545 |
| 82 | Vin Mazzaro | OAK | 17 | 423 | 91.1 | 231 | 0.547 |
| 83 | Randy Johnson | SFG | 22 | 412 | 96.0 | 223 | 0.552 |
| 84 | Garrett Olson | SEA | 31 | 347 | 80.1 | 192 | 0.555 |
| 85 | Andy Sonnanstine | TBR | 22 | 459 | 99.2 | 256 | 0.558 |
| 86 | Chris Young | SDP | 14 | 336 | 76.0 | 186 | 0.560 |
| 87 | Luke French | TOT | 15 | 312 | 67.1 | 175 | 0.561 |
| 88 | Yusmeiro Petit | ARI | 23 | 407 | 89.2 | 227 | 0.562 |
| 89 | Brett Cecil | TOR | 18 | 422 | 93.1 | 238 | 0.564 |
| 90 | Felipe Paulino | HOU | 23 | 448 | 97.2 | 251 | 0.570 |
| 91 | Tomo Ohka | CLE | 18 | 306 | 71.0 | 174 | 0.574 |
| 92 | Brett Myers | PHI | 18 | 304 | 70.2 | 173 | 0.575 |
| 93 | Kevin Hart | TOT | 18 | 374 | 81.0 | 215 | 0.580 |
| 94 | Josh Geer | SDP | 19 | 438 | 102.2 | 254 | 0.584 |
| 95 | Óliver Pérez | NYM | 14 | 324 | 66.0 | 187 | 0.586 |
| 96 | David Hernandez | BAL | 20 | 462 | 101.1 | 280 | 0.609 |
Stats sourced from Baseball-Reference