| Rank | Name | Team | G | Batters Faced | IP | TBA | TOP |
|---|---|---|---|---|---|---|---|
| 1 | Rich Harden | TOT | 25 | 595 | 148.0 | 215.0 | 0.363 |
| 2 | Justin Duchscherer | OAK | 22 | 557 | 141.2 | 208.0 | 0.374 |
| 3 | Cliff Lee | CLE | 31 | 891 | 223.1 | 337.0 | 0.379 |
| 4 | Roy Halladay | TOR | 34 | 987 | 246.0 | 381.0 | 0.388 |
| 5 | CC Sabathia | TOT | 35 | 1023 | 253.0 | 395.0 | 0.390 |
| 6 | Derek Lowe | LAD | 34 | 851 | 211.0 | 335.0 | 0.397 |
| 7 | Tim Lincecum | SFG | 34 | 928 | 227.0 | 367.0 | 0.400 |
| 8 | Brandon Webb | ARI | 34 | 944 | 226.2 | 375.0 | 0.401 |
| 9 | Hiroki Kuroda | LAD | 31 | 776 | 183.1 | 311.0 | 0.404 |
| 10 | Johan Santana | NYM | 34 | 964 | 234.1 | 389.0 | 0.407 |
| 11 | Ryan Dempster | CHC | 33 | 856 | 206.2 | 351.0 | 0.412 |
| 12 | Tim Hudson | ATL | 23 | 573 | 142.0 | 235.0 | 0.414 |
| 13 | Jake Peavy | SDP | 27 | 709 | 173.2 | 293.0 | 0.417 |
| 14 | Ervin Santana | LAA | 32 | 897 | 219.0 | 374.0 | 0.418 |
| 15 | Dan Haren | ARI | 33 | 881 | 216.0 | 367.0 | 0.420 |
| 16 | Scott Baker | MIN | 28 | 703 | 172.1 | 297.0 | 0.424 |
| 17 | Jon Lester | BOS | 33 | 874 | 210.1 | 369.0 | 0.425 |
| 18 | Adam Wainwright | STL | 20 | 544 | 132.0 | 230.0 | 0.428 |
| 19 | Roy Oswalt | HOU | 32 | 862 | 208.2 | 366.0 | 0.429 |
| 20 | Matt Garza | TBR | 30 | 772 | 184.2 | 331.0 | 0.430 |
| 21 | Ben Sheets | MIL | 31 | 812 | 198.1 | 347.0 | 0.431 |
| 22 | Chad Billingsley | LAD | 35 | 859 | 200.2 | 367.0 | 0.431 |
| 23 | Daisuke Matsuzaka | BOS | 29 | 716 | 167.2 | 308.0 | 0.432 |
| 24 | Carlos Zambrano | CHC | 30 | 796 | 188.2 | 343.0 | 0.434 |
| 25 | Cole Hamels | PHI | 33 | 914 | 227.1 | 394.0 | 0.434 |
| 26 | John Danks | CHW | 33 | 804 | 195.0 | 350.0 | 0.436 |
| 27 | Josh Beckett | BOS | 27 | 725 | 174.1 | 315.0 | 0.437 |
| 28 | Aaron Cook | COL | 32 | 886 | 211.1 | 386.0 | 0.440 |
| 29 | Ricky Nolasco | FLA | 34 | 868 | 212.1 | 380.0 | 0.441 |
| 30 | Mike Mussina | NYY | 34 | 819 | 200.1 | 360.0 | 0.442 |
| 31 | Joe Saunders | LAA | 31 | 807 | 198.0 | 354.0 | 0.442 |
| 32 | Edinson Vólquez | CIN | 33 | 838 | 196.0 | 369.0 | 0.444 |
| 33 | Zack Greinke | KCR | 32 | 851 | 202.1 | 377.0 | 0.444 |
| 34 | John Maine | NYM | 25 | 608 | 140.0 | 266.0 | 0.445 |
| 35 | Justin Verlander | DET | 33 | 880 | 201.0 | 390.0 | 0.445 |
| 36 | Mike Pelfrey | NYM | 32 | 851 | 200.2 | 374.0 | 0.445 |
| 37 | James Shields | TBR | 33 | 877 | 215.0 | 388.0 | 0.445 |
| 38 | Jesse Litsch | TOR | 29 | 735 | 176.0 | 327.0 | 0.446 |
| 39 | Paul Maholm | PIT | 31 | 853 | 206.1 | 377.0 | 0.446 |
| 40 | Shaun Marcum | TOR | 25 | 630 | 151.1 | 281.0 | 0.447 |
| 41 | Gil Meche | KCR | 34 | 886 | 210.1 | 396.0 | 0.449 |
| 42 | Wandy Rodríguez | HOU | 25 | 587 | 137.1 | 263.0 | 0.450 |
| 43 | Ubaldo Jiménez | COL | 34 | 868 | 198.2 | 388.0 | 0.451 |
| 44 | Jeremy Guthrie | BAL | 30 | 796 | 190.2 | 358.0 | 0.451 |
| 45 | Mark Buehrle | CHW | 34 | 918 | 218.2 | 416.0 | 0.454 |
| 46 | Kevin Slowey | MIN | 27 | 653 | 160.1 | 299.0 | 0.459 |
| 47 | Kyle Lohse | STL | 33 | 839 | 200.0 | 383.0 | 0.460 |
| 48 | A.J. Burnett | TOR | 35 | 957 | 221.1 | 437.0 | 0.460 |
| 49 | Greg Maddux | TOT | 33 | 804 | 194.0 | 367.0 | 0.462 |
| 50 | Matt Cain | SFG | 34 | 933 | 217.2 | 429.0 | 0.463 |
| 51 | Jamie Moyer | PHI | 33 | 841 | 196.1 | 387.0 | 0.464 |
| 52 | Greg Smith | OAK | 32 | 800 | 190.1 | 369.0 | 0.464 |
| 53 | Ryan Rowland-Smith | SEA | 47 | 506 | 118.1 | 234.0 | 0.464 |
| 54 | Todd Wellemeyer | STL | 32 | 807 | 191.2 | 372.0 | 0.464 |
| 55 | Dana Eveland | OAK | 29 | 737 | 168.0 | 341.0 | 0.465 |
| 56 | Tim Wakefield | BOS | 30 | 754 | 181.0 | 351.0 | 0.467 |
| 57 | Andy Sonnanstine | TBR | 32 | 819 | 193.1 | 381.0 | 0.467 |
| 58 | Félix Hernández | SEA | 31 | 857 | 200.2 | 400.0 | 0.469 |
| 59 | Jorge Campillo | ATL | 39 | 655 | 158.2 | 303.0 | 0.469 |
| 60 | Armando Galarraga | DET | 30 | 746 | 178.2 | 349.0 | 0.469 |
| 61 | Jair Jurrjens | ATL | 31 | 813 | 188.1 | 376.0 | 0.469 |
| 62 | Nick Blackburn | MIN | 33 | 823 | 193.1 | 385.0 | 0.471 |
| 63 | Randy Wolf | TOT | 33 | 823 | 190.1 | 383.0 | 0.471 |
| 64 | Andy Pettitte | NYY | 33 | 881 | 204.0 | 413.0 | 0.473 |
| 65 | Zach Miner | DET | 45 | 509 | 118.0 | 239.0 | 0.473 |
| 66 | John Lannan | WSN | 31 | 779 | 182.0 | 363.0 | 0.474 |
| 67 | Braden Looper | STL | 33 | 842 | 199.0 | 396.0 | 0.474 |
| 68 | Jason Marquis | CHC | 29 | 738 | 167.0 | 347.0 | 0.477 |
| 69 | Dave Bush | MIL | 31 | 763 | 185.0 | 362.0 | 0.477 |
| 70 | Joe Blanton | TOT | 33 | 855 | 197.2 | 407.0 | 0.477 |
| 71 | Óliver Pérez | NYM | 34 | 847 | 194.0 | 400.0 | 0.477 |
| 72 | Manny Parra | MIL | 32 | 741 | 166.0 | 349.0 | 0.477 |
| 73 | Randy Johnson | ARI | 30 | 778 | 184.0 | 367.0 | 0.480 |
| 74 | Roberto Hernández | CLE | 22 | 549 | 120.2 | 263.0 | 0.480 |
| 75 | José Contreras | CHW | 20 | 522 | 121.0 | 249.0 | 0.481 |
| 76 | Jered Weaver | LAA | 30 | 745 | 176.2 | 358.0 | 0.481 |
| 77 | Ted Lilly | CHC | 34 | 861 | 204.2 | 413.0 | 0.482 |
| 78 | Luke Hochevar | KCR | 22 | 566 | 129.0 | 273.0 | 0.483 |
| 79 | Scott Olsen | FLA | 33 | 855 | 201.2 | 410.0 | 0.483 |
| 80 | Barry Zito | SFG | 32 | 818 | 180.0 | 392.0 | 0.484 |
| 81 | Javier Vázquez | CHW | 33 | 890 | 208.1 | 430.0 | 0.485 |
| 82 | Doug Davis | ARI | 26 | 650 | 146.0 | 311.0 | 0.486 |
| 83 | Cha-Seung Baek | TOT | 32 | 602 | 141.0 | 292.0 | 0.487 |
| 84 | John Lackey | LAA | 24 | 675 | 163.1 | 327.0 | 0.488 |
| 85 | Scott Kazmir | TBR | 27 | 641 | 152.1 | 311.0 | 0.488 |
| 86 | Jorge De La Rosa | COL | 28 | 571 | 130.0 | 278.0 | 0.492 |
| 87 | Jonathan Sánchez | SFG | 29 | 695 | 158.0 | 339.0 | 0.494 |
| 88 | Brian Moehler | HOU | 31 | 650 | 150.0 | 318.0 | 0.495 |
| 89 | Zach Duke | PIT | 31 | 829 | 185.0 | 405.0 | 0.497 |
| 90 | Darrell Rasner | NYY | 24 | 513 | 113.1 | 253.0 | 0.499 |
| 91 | Boof Bonser | MIN | 47 | 532 | 118.1 | 264.0 | 0.499 |
| 92 | Jon Garland | LAA | 32 | 864 | 196.2 | 429.0 | 0.501 |
| 93 | Sidney Ponson | TOT | 25 | 612 | 135.2 | 307.0 | 0.503 |
| 94 | Paul Byrd | TOT | 30 | 761 | 180.0 | 381.0 | 0.503 |
| 95 | Tim Redding | WSN | 33 | 791 | 182.0 | 396.0 | 0.504 |
| 96 | Sean Gallagher | TOT | 23 | 522 | 115.1 | 262.0 | 0.505 |
| 97 | Edwin Jackson | TBR | 32 | 792 | 183.1 | 399.0 | 0.506 |
| 98 | Jarrod Washburn | SEA | 28 | 675 | 153.2 | 339.0 | 0.507 |
| 99 | Mark Hendrickson | FLA | 36 | 590 | 133.2 | 296.0 | 0.509 |
| 100 | Vicente Padilla | TEX | 29 | 757 | 171.0 | 386.0 | 0.511 |
| 101 | Bronson Arroyo | CIN | 34 | 871 | 200.0 | 442.0 | 0.515 |
| 102 | Gavin Floyd | CHW | 33 | 878 | 206.1 | 449.0 | 0.515 |
| 103 | Johnny Cueto | CIN | 31 | 769 | 174.0 | 393.0 | 0.517 |
| 104 | Brian Bannister | KCR | 32 | 811 | 182.2 | 419.0 | 0.519 |
| 105 | Glen Perkins | MIN | 26 | 661 | 151.0 | 341.0 | 0.521 |
| 106 | Kevin Correia | SFG | 25 | 514 | 110.0 | 267.0 | 0.523 |
| 107 | Brett Myers | PHI | 30 | 817 | 190.0 | 426.0 | 0.524 |
| 108 | Jeremy Sowers | CLE | 22 | 533 | 121.0 | 278.0 | 0.525 |
| 109 | Jeff Suppan | MIL | 31 | 780 | 177.2 | 404.0 | 0.525 |
| 110 | Jason Bergmann | WSN | 30 | 614 | 139.2 | 319.0 | 0.527 |
| 111 | Kevin Millwood | TEX | 29 | 767 | 168.2 | 403.0 | 0.529 |
| 112 | Odalis Pérez | WSN | 30 | 711 | 159.2 | 370.0 | 0.529 |
| 113 | Jeff Francis | COL | 24 | 636 | 143.2 | 336.0 | 0.533 |
| 114 | Joel Piñeiro | STL | 26 | 645 | 148.2 | 341.0 | 0.534 |
| 115 | Carlos Silva | SEA | 28 | 689 | 153.1 | 367.0 | 0.535 |
| 116 | Liván Hernández | TOT | 31 | 811 | 180.0 | 434.0 | 0.538 |
| 117 | Scott Feldman | TEX | 28 | 651 | 151.1 | 350.0 | 0.538 |
| 118 | Kenny Rogers | DET | 30 | 782 | 173.2 | 418.0 | 0.539 |
| 119 | Brian Burres | BAL | 31 | 596 | 129.2 | 321.0 | 0.539 |
| 120 | Daniel Cabrera | BAL | 30 | 821 | 180.0 | 444.0 | 0.544 |
| 121 | Kyle Kendrick | PHI | 31 | 722 | 155.2 | 390.0 | 0.546 |
| 122 | Aaron Harang | CIN | 30 | 793 | 184.1 | 433.0 | 0.554 |
| 123 | Ian Snell | PIT | 31 | 766 | 164.1 | 421.0 | 0.555 |
| 124 | Garrett Olson | BAL | 26 | 621 | 132.2 | 346.0 | 0.561 |
| 125 | Jo-Jo Reyes | ATL | 23 | 512 | 113.0 | 283.0 | 0.563 |
| 126 | Nate Robertson | DET | 32 | 761 | 168.2 | 426.0 | 0.563 |
| 127 | Brandon Backe | HOU | 31 | 756 | 166.2 | 443.0 | 0.589 |
| 128 | Miguel Batista | SEA | 44 | 556 | 115.0 | 335.0 | 0.606 |
Stats sourced from Baseball-Reference