| Rank | Name | Team | G | Batters Faced | IP | TBA | TOP |
|---|---|---|---|---|---|---|---|
| 1 | Heath Bell | SDP | 81 | 363 | 93.2 | 117 | 0.327 |
| 2 | Manny Corpas | COL | 78 | 306 | 78.0 | 108 | 0.355 |
| 3 | Matt Capps | PIT | 76 | 315 | 79.0 | 112 | 0.359 |
| 4 | Lee Gardner | FLA | 62 | 311 | 74.1 | 115 | 0.373 |
| 5 | Jon Rauch | WSN | 88 | 354 | 87.1 | 138 | 0.392 |
| 6 | Jonathan Broxton | LAD | 83 | 334 | 82.0 | 131 | 0.392 |
| 7 | Ryan Franklin | STL | 69 | 317 | 80.0 | 124 | 0.394 |
| 8 | Peter Moylan | ATL | 80 | 359 | 90.0 | 141 | 0.397 |
| 9 | Matt Guerrier | MIN | 73 | 351 | 88.0 | 140 | 0.399 |
| 10 | Joaquín Benoit | TEX | 70 | 337 | 82.0 | 135 | 0.404 |
| 11 | Tony Peña | ARI | 75 | 344 | 85.1 | 141 | 0.411 |
| 12 | Saúl Rivera | WSN | 85 | 398 | 93.0 | 162 | 0.412 |
| 13 | Brandon Lyon | ARI | 73 | 307 | 74.0 | 126 | 0.414 |
| 14 | Kevin Gregg | FLA | 74 | 355 | 84.0 | 146 | 0.415 |
| 15 | Scot Shields | LAA | 71 | 320 | 77.0 | 133 | 0.416 |
| 16 | Aaron Heilman | NYM | 81 | 352 | 86.0 | 145 | 0.417 |
| 17 | Bob Howry | CHC | 78 | 336 | 81.1 | 140 | 0.422 |
| 18 | Doug Brocail | SDP | 67 | 319 | 76.2 | 134 | 0.423 |
| 19 | Shawn Hill | WSN | 16 | 399 | 97.1 | 168 | 0.423 |
| 20 | Yovani Gallardo | MIL | 20 | 466 | 110.1 | 197 | 0.426 |
| 21 | David Weathers | CIN | 70 | 328 | 77.2 | 140 | 0.433 |
| 22 | Cla Meredith | SDP | 80 | 342 | 79.2 | 148 | 0.434 |
| 23 | Jason Grilli | DET | 57 | 352 | 79.2 | 152 | 0.434 |
| 24 | Kevin Correia | SFG | 59 | 437 | 101.2 | 194 | 0.448 |
| 25 | Óscar Villarreal | ATL | 51 | 336 | 76.1 | 151 | 0.453 |
| 26 | Chad Qualls | HOU | 79 | 345 | 82.2 | 154 | 0.454 |
| 27 | Jorge Sosa | NYM | 42 | 481 | 112.2 | 214 | 0.454 |
| 28 | Chad Cordero | WSN | 76 | 321 | 75.0 | 146 | 0.458 |
| 29 | Sean Green | SEA | 64 | 304 | 68.0 | 138 | 0.460 |
| 30 | Kason Gabbard | TOT | 15 | 344 | 81.1 | 159 | 0.464 |
| 31 | Dustin Moseley | LAA | 46 | 383 | 92.0 | 178 | 0.466 |
| 32 | Jamey Wright | TEX | 20 | 330 | 77.0 | 152 | 0.466 |
| 33 | Phil Hughes | NYY | 13 | 306 | 72.2 | 142 | 0.467 |
| 34 | Taylor Buchholz | COL | 41 | 396 | 93.2 | 183 | 0.468 |
| 35 | Cha-Seung Baek | SEA | 14 | 321 | 73.1 | 150 | 0.469 |
| 36 | Roger Clemens | NYY | 18 | 420 | 99.0 | 196 | 0.469 |
| 37 | Luis Vizcaíno | NYY | 77 | 334 | 75.1 | 156 | 0.470 |
| 38 | Matt Garza | MIN | 16 | 367 | 83.0 | 172 | 0.470 |
| 39 | Randy Wolf | LAD | 18 | 458 | 102.2 | 215 | 0.475 |
| 40 | Sean Marshall | CHC | 21 | 446 | 103.1 | 209 | 0.476 |
| 41 | Joe Kennedy | TOT | 36 | 482 | 108.0 | 227 | 0.477 |
| 42 | Michael Wuertz | CHC | 73 | 312 | 72.1 | 148 | 0.479 |
| 43 | Rudy Seánez | LAD | 73 | 329 | 76.0 | 157 | 0.480 |
| 44 | Chris Bootcheck | LAA | 51 | 331 | 77.1 | 158 | 0.480 |
| 45 | Tim Redding | WSN | 15 | 366 | 84.0 | 173 | 0.481 |
| 46 | Joe Kennedy | TOT | 39 | 501 | 110.2 | 238 | 0.481 |
| 47 | Jesse Litsch | TOR | 20 | 478 | 111.0 | 229 | 0.482 |
| 48 | Jon Lieber | PHI | 14 | 342 | 78.0 | 165 | 0.485 |
| 49 | Scott Proctor | TOT | 83 | 382 | 86.1 | 184 | 0.485 |
| 50 | Todd Wellemeyer | TOT | 32 | 353 | 79.1 | 170 | 0.486 |
| 51 | Joe Saunders | LAA | 18 | 473 | 107.1 | 231 | 0.488 |
| 52 | Carlos Villanueva | MIL | 59 | 489 | 114.1 | 237 | 0.489 |
| 53 | Jason Bergmann | WSN | 21 | 480 | 115.1 | 232 | 0.489 |
| 54 | Shawn Chacón | PIT | 64 | 428 | 96.0 | 206 | 0.493 |
| 55 | Kyle Kendrick | PHI | 20 | 499 | 121.0 | 245 | 0.495 |
| 56 | Dan Wheeler | TOT | 70 | 321 | 74.2 | 158 | 0.497 |
| 57 | Rodrigo López | COL | 14 | 333 | 79.1 | 164 | 0.497 |
| 58 | Joel Peralta | KCR | 62 | 366 | 87.2 | 182 | 0.500 |
| 59 | Dave Borkowski | HOU | 64 | 325 | 71.2 | 163 | 0.506 |
| 60 | Willie Eyre | TEX | 33 | 307 | 68.0 | 154 | 0.510 |
| 61 | Brandon McCarthy | TEX | 23 | 459 | 101.2 | 234 | 0.513 |
| 62 | Édgar González | ARI | 32 | 437 | 102.0 | 223 | 0.514 |
| 63 | Joel Piñeiro | TOT | 42 | 419 | 97.2 | 214 | 0.514 |
| 64 | Jason Hirsh | COL | 19 | 483 | 112.1 | 247 | 0.518 |
| 65 | J.D. Durbin | TOT | 19 | 305 | 65.1 | 156 | 0.518 |
| 66 | Anthony Reyes | STL | 22 | 474 | 107.1 | 246 | 0.520 |
| 67 | Ubaldo Jiménez | COL | 15 | 354 | 82.0 | 183 | 0.521 |
| 68 | Ramón Ortiz | TOT | 38 | 459 | 104.0 | 239 | 0.522 |
| 69 | Dallas Braden | OAK | 20 | 332 | 72.1 | 172 | 0.524 |
| 70 | Bartolo Colón | LAA | 19 | 453 | 99.1 | 236 | 0.526 |
| 71 | Mike Pelfrey | NYM | 15 | 342 | 72.2 | 177 | 0.527 |
| 72 | Gary Glover | TBD | 67 | 334 | 77.1 | 179 | 0.538 |
| 73 | Cliff Lee | CLE | 20 | 443 | 97.1 | 239 | 0.543 |
| 74 | Josh Towers | TOR | 25 | 469 | 107.0 | 254 | 0.545 |
| 75 | Andrew Miller | DET | 13 | 309 | 64.0 | 167 | 0.546 |
| 76 | Tony Armas | PIT | 31 | 442 | 97.0 | 244 | 0.555 |
| 77 | Buddy Carlyle | ATL | 22 | 462 | 107.0 | 251 | 0.557 |
| 78 | Jeremy Sowers | CLE | 13 | 303 | 67.1 | 169 | 0.558 |
| 79 | Horacio Ramírez | SEA | 20 | 459 | 98.0 | 259 | 0.567 |
| 80 | Zach Duke | PIT | 20 | 482 | 107.1 | 273 | 0.569 |
| 81 | Jason Jennings | HOU | 19 | 445 | 99.0 | 254 | 0.579 |
| 82 | Jason Simontacchi | WSN | 13 | 322 | 70.2 | 184 | 0.579 |
| 83 | Rob Tejeda | TEX | 19 | 454 | 95.1 | 262 | 0.581 |
| 84 | Jason Hammel | TBD | 24 | 384 | 85.0 | 223 | 0.584 |
| 85 | Gavin Floyd | CHW | 16 | 314 | 70.0 | 184 | 0.592 |
| 86 | Kei Igawa | NYY | 14 | 313 | 67.2 | 186 | 0.594 |
| 87 | Rick van den Hurk | FLA | 18 | 379 | 81.2 | 225 | 0.602 |
| 88 | Casey Fossum | TBD | 40 | 364 | 76.0 | 219 | 0.605 |
Stats sourced from Baseball-Reference